MCI Multispecialty Grand Rounds – Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC)
Peritoneal carcinomatosis remains a diagnostic challenge with sparse treatment options. The effect of systemic chemotherapy remains limited inside the peritoneum due to low penetration and a relative resistance of peritoneal nodules. Heated IntraPeritoneal Chemotherapy (HIPEC) improves survival in selected patients but entails a high incidence of complications. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) allows to disperse the active agents inside the peritoneal cavity by laparoscopy. Distribution and tissue penetration of chemotherapy by PIPAC appear superior to HIPEC and systemic chemotherapy despite of the use of lower doses.
Oncologists, Radiation Oncologists, Hematology Oncologists, Radiation Therapists, General Surgeons, General Practitioners, Obstetricians and Gynecologists, Nurses, Social Workers, Patient Navigators and all other interested healthcare professionals.
- Implement the concept of Pressurized Intra Peritoneal Aerosol Chemotherapy (PIPAC) in patient selection and indications.
- Discuss oncologic outcomes and morbidity and mortality of the procedure.
- Compare outcomes between PIPAC and HIPEC.
- Discuss the international registry of patients treated with PIPAC.
Nicolas Demartines, M.D., FACS, FRCS, hon FCCS
Professor and Chairman
Département Surgery University Hospital of Lausanne
Nicolas Demartines, M.D., indicated that neither he nor his spouse/partner has relevant financial relationships with commercial interest companies, and he will not include off-label or unapproved product usage in his presentation(s) or discussion(s).
Non-faculty contributors and others involved in the planning, development, and editing/review of the content have relevant financial relationships to disclose.
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