Immunotherapy for Pediatric Cancer

CAR T-cell therapy is a promising new treatment for some of the most challenging cases faced in pediatric cancers. During this course, participants will become familiar with current T-cell therapy approaches.  Dr. Gottschalk will also explain how T-cells are generated and used in clinical settings.

Target Audience

Pediatricians, Pediatric Oncologists, Hematologists/Oncologists, Infectious Disease Pediatricians, Pediatric General Internists, Family Physicians, Neonatologists, ED Physicians, Physician Assistants, Nurses, Advanced Practice Registered Nurses, Respiratory Therapists (Personal Growth) and all other interested healthcare providers who care for children with cancer.

Learning Objectives

  • Implement immune-based therapies underlying target selection. 
  • Assess the potential of implementing tumor-specific translocations. 
Additional information
Bibliography: 
  • Bhojwani, D., Sposto, R., Shah, N. N., Rodriguez, V., Yuan, C., Stetler-Stevenson, M., ... & Schlegel, P. (2019). Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. Leukemia, 33(4), 884-892.
  • Tzannou, I., Papadopoulou, A., Naik, S., Leung, K., Martinez, C. A., Ramos, C. A., ... & Kuvalekar, M. (2017). Off-the-shelf virus-specific T cells to treat BK virus, human herpesvirus 6, cytomegalovirus, Epstein-Barr virus, and adenovirus infections after allogeneic hematopoietic stem-cell transplantation. Journal of Clinical Oncology, 35(31), 3547.
  • Eshhar, Z., Waks, T., Gross, G., & Schindler, D. G. (1993). Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proceedings of the National Academy of Sciences, 90(2), 720-724.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Respiratory Therapy
Course opens: 
03/01/2020
Course expires: 
02/28/2023

Stephen Gottschalk, M.D. 
Chair, Department of Bone Marrow Transplantation and Cellular Therapy
Endowed Chair in Bone Marrow Transplantation and Cellular Therapy
St. Jude’s Children’s Hospital 
Memphis, Tennessee

Stephen Gottshalk, M.D., has indicated that he has patents and patent applications in the fields of T-cell and gene therapy for cancer, has a research collaboration with TESSA Therapeutics, is a DSMB/SAB member for Immatics and Tidal and has been a consultant for Merck, Allovir and PACT. 

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.

Symposium Directors

Doured Daghistani, M.D.
Symposium Director
Hematology/Oncology
Baptist, Homestead and South Miami Hospitals
Miami, Florida

Ziad Khatib, M.D. 
Director of Medical Neuro-Oncology
Division of Pediatric Hematology/Oncology
Clinical Associate Professor
Department of Pediatrics
Florida International University
Kidz Medical Services
Nicklaus Children’s Hospital
Miami, Florida

Doured Dahgistani, M.D., and Ziad Khatib, M.D., have indicated that neither they nor their spouse/partner have relevant financial relationships with commercial interest companies, and they will not include off-label or unapproved product usage in their presentation or discussion.

Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose.
 

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
              
Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Respiratory Therapy
Please login or register to take this course.

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