Immunotherapy for Pediatric Cancer

CAR T-cell therapy is a promising new treatment for some of the most challenging cases faced in pediatric cancers. During this course, participants will become familiar with current T-cell therapy approaches.  Dr. Gottschalk will also explain how T-cells are generated and used in clinical settings.

Target Audience

Pediatricians, Pediatric Oncologists, Hematologists/Oncologists, Infectious Disease Pediatricians, Pediatric General Internists, Family Physicians, Neonatologists, ED Physicians, Physician Assistants, Nurses, Advanced Practice Registered Nurses, Respiratory Therapists (Personal Growth) and all other interested healthcare providers who care for children with cancer.

Learning Objectives

  • Implement immune-based therapies underlying target selection. 
  • Assess the potential of implementing tumor-specific translocations. 
Additional information
Bibliography: 
  • Bhojwani, D., Sposto, R., Shah, N. N., Rodriguez, V., Yuan, C., Stetler-Stevenson, M., ... & Schlegel, P. (2019). Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia. Leukemia, 33(4), 884-892.
  • Tzannou, I., Papadopoulou, A., Naik, S., Leung, K., Martinez, C. A., Ramos, C. A., ... & Kuvalekar, M. (2017). Off-the-shelf virus-specific T cells to treat BK virus, human herpesvirus 6, cytomegalovirus, Epstein-Barr virus, and adenovirus infections after allogeneic hematopoietic stem-cell transplantation. Journal of Clinical Oncology, 35(31), 3547.
  • Eshhar, Z., Waks, T., Gross, G., & Schindler, D. G. (1993). Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors. Proceedings of the National Academy of Sciences, 90(2), 720-724.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Respiratory Therapy
Course opens: 
03/01/2020
Course expires: 
02/28/2023

Stephen Gottschalk, M.D. 
Chair, Department of Bone Marrow Transplantation and Cellular Therapy
Endowed Chair in Bone Marrow Transplantation and Cellular Therapy
St. Jude’s Children’s Hospital 
Memphis, Tennessee

Stephen Gottshalk, M.D., has indicated that he has patents and patent applications in the fields of T-cell and gene therapy for cancer, has a research collaboration with TESSA Therapeutics, is a DSMB/SAB member for Immatics and Tidal and has been a consultant for Merck, Allovir and PACT. 

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.

Symposium Directors

Doured Daghistani, M.D.
Symposium Director
Hematology/Oncology
Baptist, Homestead and South Miami Hospitals
Miami, Florida

Ziad Khatib, M.D. 
Director of Medical Neuro-Oncology
Division of Pediatric Hematology/Oncology
Clinical Associate Professor
Department of Pediatrics
Florida International University
Kidz Medical Services
Nicklaus Children’s Hospital
Miami, Florida

Doured Dahgistani, M.D., and Ziad Khatib, M.D., have indicated that neither they nor their spouse/partner have relevant financial relationships with commercial interest companies, and they will not include off-label or unapproved product usage in their presentation or discussion.

Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose.
 

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
              
Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Respiratory Therapy
Please login or register to take this course.

Required Hardware/software

PC/Mac Users
PC/Mac Users

This site is supported on the most recent stable releases of the following browsers:

Click Here to Download Google Chrome
Google Chrome
Microsoft Edge
Microsoft Edge
Safari
Safari
Moxilla Firefox
Mozilla Firefox
Internet Explorer

Attention: Internet Explorer Users
This site offers limited support for Internet Explorer 11 (IE11). When using IE11, you will be prompted to download course videos instead of viewing them in the browser. After the course video downloads, the recordings will play.

Mobile Users
Mobile Users

This site is supported on the following mobile devices:

  • Apple iOS mobile devices running iOS 10 or later
  • Android mobile devices running Android 4.4 or later, with the latest release of Google Chrome or Mozilla Firefox
Technical Support
Technical Support

If you are experiencing technical difficulties or have received an error message, please send an email to CME@baptisthealth.net and include a print screen of the error message, your browser name and version, username and URL where the error occurred. You can expect a response within 48 hours.