| Describe the temporal changes in diffuse fibrosis, dense fibrosis, and tumor oxygenation (hypoxia) during external beam radiation therapy (EBRT) for cervical cancer, based on longitudinal MRI assessment. |
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| Evaluate the impact of fibrosis and hypoxia dynamics on tumor response to subsequent radiation dose fractions and overall treatment effectiveness. |
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| Assess emerging strategies to address severe tumor hypoxia, including brachytherapy-based dose escalation, interventions to improve tumor oxygenation, and approaches designed to mitigate fibrosis-related perfusion deficits in order to optimize treatment outcomes. |
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