A Fluoroquinolone Story: 1960s to Present

Fluoroquinolones are commonly prescribed antimicrobial agents used to treat a variety of bacterial infections. While effective, these medications are associated with significant safety concerns that require careful consideration when selecting therapy. This course examines the clinical indications for fluoroquinolone use, reviews current safety warnings and adverse effects, and explores situations in which fluoroquinolones may be the preferred treatment option versus when alternative therapies should be considered.

Target Audience

Internal Family Medicine Physicians, Urgent Care Physicians, Physician Assistants/Physician Associates, Advanced Practice Registered Nurses, Nurses, Pharmacists, Pharmacy Technicians, Hospitalists and all other interested healthcare providers.

Learning Objectives

At the conclusion, participants should be able to:

  • Explain the history of fluoroquinolones in clinical practice and delineate concerns related to their safety. 
  • Utilize the Food and Drug Administration guidelines regarding the appropriate use of fluoroquinolones in clinical practice.
  • Counsel patients regarding the potential unintended consequences of fluoroquinolones. 
  • Document in the medical record reasons for prescribing when alternatives have been exhausted.
Additional information
Bibliography: 
  • Morales, D., Pacurariu, A., Slattery, J., Pinheiro, L., McGettigan, P., & Kurz, X. (2019). Association between peripheral neuropathy and exposure to oral fluoroquinolone or amoxicillin-clavulanate therapy. JAMA neurology, 76(7), 827-833.
  • Brown, K. A., Schwartz, K., Langford, B., Diong, C., Garber, G., & Daneman, N. (2019, October). 2369. Prescribing Choices and C. difficile Infection Risk: A Longitudinal Cohort Study of Nursing Home Residents in Ontario, Canada. In Open Forum Infectious Diseases (Vol. 6, No. Suppl 2, p. S817). Oxford University Press.
  • Simner, P. J., Rauch, C. A., Martin, I. W., Sullivan, K. V., Rhoads, D., Rolf, R., ... & Humphries, R. M. (2022, March). Raising the bar: improving antimicrobial resistance detection by clinical laboratories by ensuring use of current breakpoints. In Open forum infectious diseases (Vol. 9, No. 3, p. ofac007). US: Oxford University Press.
  • Iregui, A., Khan, Z., Malik, S., Landman, D., & Quale, J. (2020). Emergence of delafloxacin-resistant Staphylococcus aureus in Brooklyn, New York. Clinical Infectious Diseases, 70(8), 1758-1760.
Course Summary
Available credit: 
  • 1.00 ABIM Medical Knowledge
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Pharmacy
Course opens: 
08/07/2026
Course expires: 
08/06/2029

Faculty

Timothy P. Gauthier, Pharm.D., BCPS, BCIDP 
Director, ID PGY2 Pharmacy Residency Program 
Manager, Antimicrobial Stewardship Clinical Program 
Baptist Health South Florida 
Miami, Florida 

Elise McCormack-Granja, M.D.
Lead Primary Care Physician
Baptist Health Medical Group
Associate Program Director
Internal Medicine Residency
Baptist Health South Florida
Miami, Florida

Adaeze “Chika” Ohaeto, DNP, APRN-BC
Manager of Advanced Practice Providers
Primary Care
Baptist Health South Florida
Miami, Florida


Timothy Gauthier, PharmD, faculty for this educational activity, is a consultant for Pattern Biosciences (formerly Klaris Diagnostics), an independent contractor for MeMEd and a consultant for Pfizer and DoseMeRx by Tabula Rasa. He has indicated that the presentation or discussion will not include off-label or unapproved product usage.

Elise McCormack Granja, M.D., director of this educational activity has no relevant financial relationships with any ineligible companies to disclose.

Adaeze “Chika” Ohaeto, APRN, coordinator of this educational activity has no relevant financial relationships with any ineligible companies to disclose.

Non-faculty contributors and others involved in the planning, development, and editing/review of the content have relevant financial relationships to disclose with ineligible companies*

*Ineligible companies - Companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.


Artificial Intelligence (AI) Use Disclosure

For this activity, AI was used to assist in developing and refining assessment questions and learner feedback based on medical writer-authored content, and to help align assessments with competency-level outcome measures consistent with ACCME standards. All AI-assisted content received subject matter expert review, validation, and approval before use.
 

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.

Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Your participation information will be shared with specialty boards through the ACCME's PARS reporting system. Successful completion of a course examination is required. Submissions are recorded in approximately 48 hours. You will receive an email when your credits have been processed.

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Available Credit

  • 1.00 ABIM Medical Knowledge
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Pharmacy
Please login or register for a Baptist Health CME account to take this course.

Your participation information will be shared with specialty boards through the ACCME's PARS reporting system. Successful completion of a course examination is required. Submissions are recorded in approximately 48 hours. You will receive an email when your credits have been processed.

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