| Differentiate acute, chronic, and acute-on-chronic pain mechanisms in SCD. |
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| Apply the ASH 2020 guidelines to acute vaso-occlusive pain, including rapid individualized opioid dosing and multimodal analgesia. |
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| Assess subanesthetic ketamine as an adjunct for refractory acute pain. |
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| Understand the use of buprenorphine in chronic pain management |
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| Outline buprenorphine transition (standard and microdosing) for chronic SCD pain. |
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