Optimizing Adoptive Cell Immunotherapeutics Via GPS

Robert Sackstein, M.D., discusses the next steps in immunotherapy and how improved delivery of vascularly administered, culture-expanded immune effector cells (e.g., CAR T-cells) can be achieved. 

Target Audience

Hematologists, oncologists, pathologists, radiation oncologists, oncology/hematology nurses, nurse practitioners, physician assistants, palliative care staff, pharmacists and other allied health care team members interested in the treatment of patients with hematologic malignancies.

Learning Objectives

  • Identify the molecular basis of cell migration. 
  • Illustrate how site-specific migration cells can be achieved for adoptive immunotherapy applications.
  • Explain how to execute improved site-specific cell trafficking, yielding higher efficacy, safer outcomes and lower costs for adoptive immunotherapy applications.

Sponsors 

The Continuing Medical Education Department gratefully acknowledges the following organizations for providing support of high quality unbiased continuing medical education at the Immunotherapy Symposium, at which the content for this online activity was recorded:
 
Bristol-Meyers Squibb
Genentech
Janssen Oncology
Jazz Pharmaceuticals, Inc.

Additional information
Bibliography: 
  • Mikkilineni, L., & Kochenderfer, J. N. (2017). Chimeric antigen receptor T-cell therapies for multiple myeloma. Blood, The Journal of the American Society of Hematology, 130(24), 2594-2602.
  • Sackstein, R. (2016). Fulfilling Koch's postulates in glycoscience: HCELL, GPS and translational glycobiology. Glycobiology, 26(6), 560-570.
  • Dimitroff, C. J., Lee, J. Y., Rafii, S., Fuhlbrigge, R. C., & Sackstein, R. (2001). CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. The Journal of cell biology, 153(6), 1277-1286.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Pharmacy
Course opens: 
06/01/2020
Course expires: 
02/28/2023

Robert Sackstein, M.D.
Interim Chair, Department of Translational Medicine
Dean and Senior Vice President for Health Affairs, and Professor
Florida International University
Miami, Florida

This online course is a highlight from the Inaugural Miami Cancer Institute Immunotherapies Summit.

Guenther Koehne, M.D., Ph.D.
Deputy Director of Miami Cancer Institute
Chief of Blood & Marrow Transplant and Hematologic Oncology
Miami Cancer Institute 
Miami, Florida

Guenther Koehne, M.D., Ph.D., has indicated that neither he nor his spouse/partner has relevant financial relationships with commercial interest companies, and he will not include off-label or unapproved product usage in his presentation or discussion.

Robert Sackstein, M.D., has indicated that he is a consultant with Biotechne/R&D Systems and Mesoblast Ltd., and he has licenses with Warrior Therapeutics LLC, Mesoblast Ltd., and Biotechne/R&D Systems. He also has equity with Warrior Therapeutics, LLC. He will not include off-label or unapproved product usage in his presentation or discussion.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
              
Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Pharmacy
Please login or register to take this course.

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