Innovation in Neoadjuvant Chemotherapy Are We Ready to Move Beyond Large Phase 3 Confirmatory Trials?

This course will explain the concept and research supporting precision medicine and the scientific process of targeted escalation and de-escalation of care to increase efficacy and reduce morbidity.

Target Audience

Obstetricians, Gynecologists, General Surgeons, General Practitioners, Family Physicians, Oncologists, Physician Assistants, Nurse Practitioners, Nurse Midwives and Pharmacists.

Learning Objectives

  • Compare results from neoadjuvant breast cancer trials and their confirmatory phase 3 adjuvant trials.
  • Describe results from the I SPY 2 adaptive platform trial in breast cancer.
  • Reconcile the recent adjuvant trials showing that both more therapy and less therapy are better.
  • Assess a more personalized approach to patient treatment.
Additional information
  • Rugo, H. S., Olopade, O. I., DeMichele, A., Yau, C., van’t Veer, L. J., Buxton, M. B., ... & Symmans, W. F. (2016). Adaptive randomization of veliparib–carboplatin treatment in breast cancer. New England Journal of Medicine, 375(1), 23-34.
  • Park, J. W., Liu, M. C., Yee, D., Yau, C., van’t Veer, L. J., Symmans, W. F., ... & DeMichele, A. (2016). Adaptive randomization of neratinib in early breast cancer. New England Journal of Medicine, 375(1), 11-22.
  • Von Minckwitz, G., Procter, M. J., De Azambuja, E., Zardavas, D., Knott, A., Viale, G., ... & Benyunes, M. (2017). APHINITY trial (BIG 4-11): A randomized comparison of chemotherapy (C) plus trastuzumab (T) plus placebo (Pla) versus chemotherapy plus trastuzumab (T) plus pertuzumab (P) as adjuvant therapy in patients (pts) with HER2-positive early breast cancer (EBC).
  • Yee, D et al: Pathological complete response predicts event-free and distant disease free survival in the I-SPY2 TRIAL  SABCS 2017 (in press)
Course Summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Pharmacy
Course opens: 
Course expires: 

Laura Esserman, M.D., MBA
Professor, Departments of Surgery and Radiology
Affiliate Faculty, Institute for Health Policy Studies
University of California San Francisco (UCSF)
Director, Carol Franc Buck Breast Care Center
Co-Leader, Breast Oncology Program, UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California

Laura Esserman, M.D., MBA, indicated that neither she nor her spouse/partner has relevant financial relationships with commercial interest companies, and she will not include off-label or unapproved product usage in her presentation or discussion.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Pharmacy
Please login or register for a Baptist Health CME account to take this course.

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