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ForwardMiami Heart Study - Subclinical Atherosclerosis and the Genetics of Cardiovascular Medicine
Cardiovascular disease is the leading contributor to years lost due to disability or premature death among adults. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and accounts for a large share of total healthcare expenditure.
While CVD risk assessment in general has been traditionally guided by risk estimates derived from scores combining traditional risk factors, there is a growing body of evidence showing that such an approach lacks sufficient accuracy in predicting risk of future events among asymptomatic individuals. Substantial progress has been made in the discovery of genetic characterization contributing to the risk of coronary artery disease and the refinement of polygenic risk scores.
Dr. Theodore Feldman, Dr. Khurram Nasir and Dr. Ricardo Cury discuss how the Miami Heart Study at Baptist Health South Florida aims to provide important, novel insights into the pathophysiology of early subclinical atherosclerosis and further the understanding of its role in the genesis of clinical CVD.
Dr. Pradeep Natarajan discusses the evidence supporting the use of both clinical and genetic risk scoring to predict incident coronary artery disease and indicate the clinical response to some preventive therapies.
Topics include:
- Lessons from the Miami Heart Study: Imaging Insights
- Miami Heart Study Update
- Miami Heart Study (MiHeart) at Baptist Health South Florida
- Applications of Genetics to Cardiovascular Medicine
Commercial Supporter
Baptist Health gratefully acknowledges the educational grants provided by Novartis.
Target Audience
Cardiologists, interventional cardiologists, cardiothoracic surgeons, vascular surgeons, interventional radiologists, echocardiographers, pulmonologists, hematologists, general internists, primary care physicians, intensivists, emergency medicine physicians, hospitalists, nurses, pharmacists, respiratory technologists and other interested healthcare providers.
Learning Objectives
- Assess and characterize the presence and severity of subclinical cardiovascular disease (CVD) burden among middle-aged asymptomatic individuals.
- Determine the relationships and interplay of traditional risk factors, lifestyle and behavioral factors as well as biomarkers (traditional and novel) related to the presence and burden of subclinical CVD among middle-aged asymptomatic individuals.
- Apply population-based methods of screening for cardiovascular risk among middle-aged asymptomatic persons.
- Utilize cost-effective resources for early CVD management.
- Recognize the contribution of genetic factors to atherosclerotic cardiovascular disease.
- Describe the clinical utility of genetic factors to prioritize therapeutic targets and causal biomarkers.
- Outline the evidence supporting a clinical role of polygenic risk scoring in coronary artery disease prevention.
Ricardo C. Cury, M.D., MBA, MSCCT, FACR, FAHA, FACC
Chairman of Radiology
Radiology Associates of South Florida
Director of Cardiac Imaging
Miami Cardiac & Vascular Institute and Baptist Health South Florida
Professor and Chairman of Radiology
Florida International University Herbert Wertheim College of Medicine
Theodore Feldman, M.D., FACC, FACP
Medical Director, Prevention and Community Health
Co-Medical Director, The Cardiometabolic and Cardiac Prevention Center
Miami Cardiac & Vascular Institute
Baptist Health South Florida
Co-Principal Investigator
Chairman, Publications and Proposals Committee, Miami Heart Study
Head of Cardiology and Clinical Associate Professor of Medicine
Florida International University Herbert Wertheim College of Medicine
Khurram Nasir, M.D., MPH, MSc
Principal Investigator, Miami Heart Study at Baptist Health South Florida
Chief Division of Cardiovascular Prevention and Wellness
Houston Methodist DeBakey Heart & Vascular Center
Director Center for Computational Health and Precision Health (C3-PH)
Professor of Cardiology, Houston Methodist Academic Institute
Professor of Medicine, Weil Cornell Medical College
Visiting Professor, London School of Economics (LSE)
Pradeep Natarajan, M.D., MMSc
Director of Preventive Cardiology, Massachusetts General Hospital
Paul & Phyllis Fireman Endowed Chair in Vascular Medicine, Massachusetts General Hospital
Associate Professor of Medicine, Harvard Medical School
Associate Member, Broad Institute of Harvard and MIT
Ricardo C. Cury, M.D., MBA, faculty for this educational activity, is a consultant for GE Healthcare, Covera Health and Cleerly, and is a shareholder in Cleerly. He has indicated that the presentation or discussion will not include off-label or unapproved product usage.
Khurram Nasir, M.D., MPH, faculty for this educational activity, is a consultant for Amgen, Novartis and Novo Nordisk. He has indicated that the presentation or discussion will not include off-label or unapproved product usage.
Theodore Feldman, M.D., faculty and director of this educational activity, is on the speakers’ bureau for Novo Nordisk. He has indicated that the presentation or discussion will include off-label or unapproved product usage.
Pradeep Natarajan, M.D., MMSc, faculty for this educational activity, is a consultant for Genentech/Roche, Foresite Labs, Blackstone Life Sciences, Novartis and Allelica, and has other financial relationships with GeneXwell, TenSixteen Bio and Esperion Therapeutics. He has indicated that the presentation or discussion will not include off-label or unapproved product usage.
All of the relevant financial relationships listed for these individuals have been mitigated.
Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships with ineligible companies* to disclose.
*Ineligible companies ¬– Companies whose primary business is producing, marketing, selling, re-selling or distributing healthcare products used by or on patients.
Disclosure Policy and Disclaimer
Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
Baptist Health South Florida designates this enduring material for a maximum of 2 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
American Board of Surgery - Accredited CME - General Surgery
Successful completion of this CME activity enables the learner to earn credit toward the CME requirements of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.
Your participation information will be shared with specialty boards through the ACCME's PARS reporting system. Successful completion of a course examination is required. Submissions are recorded in approximately 48 hours. You will receive an email when your credits have been processed.
Available Credit
- 2.00 ABS MOC II
- 2.00 AMA PRA Category 1 Credit™
- 2.00 General certificate of attendance
- 2.00 Nurse Practitioners
- 2.00 Florida Board of Nursing
- 2.00 Florida Board of Pharmacy
- 2.00 Florida Board of Respiratory Therapy
Your participation information will be shared with specialty boards through the ACCME's PARS reporting system. Successful completion of a course examination is required. Submissions are recorded in approximately 48 hours. You will receive an email when your credits have been processed.
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