The IMPROVE-IT Trial: Lessons Learned and Clinical Implications
IMPROVE-IT is a randomized, active-control, double-blind study of subjects with stabilized high-risk acute coronary syndrome. The primary objective is to evaluate the clinical benefit of lowering LDL-cholesterol in high-risk patients with the non-statin agent ezetimibe in addition to statin therapy to further reduce cardiovascular events.
Target Audience
Cardiologists, Endocrinologists, Family Physicians, General Internists, Gynecologists and Physician Assistants.
Learning Objectives
- Discuss the incremental clinical benefit of lowering LDL-cholesterol in high-risk patients with the non-statin agent ezetimibe in addition to statin therapy to further reduce cardiovascular events.
- Recognize that the LDL-cholesterol hypothesis ("lower is better") was supported by the IMPROVE-IT Trial.
- Discuss the safety of ezetimibe.
Michael Ozner, M.D., FACC, FAHA
Medical Director, Center for Prevention and Wellness
Baptist Health South Florida
Voluntary Assistant Professor of Medicine (Cardiology)
University of Miami Miller School of Medicine
Miami, Florida
Michael Ozner, M.D., FACC, FAHA, indicated that neither he nor his spouse/partner has relevant financial relationships with commercial interest companies, and he will not include off-label or unapproved product usage in his presentations or discussions.
Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.
Available Credit
- 0.50 AMA PRA Category 1 Credit™
- 0.50 General certificate of attendance
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