Immuno-Oncology (IO) Therapies for Colorectal Cancer Liver Metastases

Surgical resection remains the primary curative treatment option for patients with colorectal liver metastases. During this course, Dr. Sofocleous will discuss the potential initiating treatment with immuno-oncology instead of tumor resection.   

Target Audience

Oncologists, Radiation Oncologists, Hematology Oncologists, General Surgeons, General Practitioners, Obstetricians and Gynecologists, Patient Navigators, Nurse Practitioners and all other interested healthcare professionals.

Learning Objectives

  • Determine when to implement ablation instead of resection, assessing the tumor and considering patient selection criteria. 
  • Implement evidence-based best practices for intra-arterial therapy for colon rectal cancer (CRC) liver metastases.
  • Discuss future directions to optimize IO therapies for CRC liver metastases. 
Additional information
Bibliography: 
  • Gillams, A., Goldberg, N., Ahmed, M., Bale, R., Breen, D., Callstrom, M., ... & Solbiati, L. (2015). Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, The Interventional Oncology Sans Frontières meeting 2013. European radiology, 25(12), 3438-3454.
  • Meijerink, M. R., Puijk, R. S., van Tilborg, A. A., Henningsen, K. H., Fernandez, L. G., Neyt, M., ... & Vlayen, J. (2018). Radiofrequency and microwave ablation compared to systemic chemotherapy and to partial hepatectomy in the treatment of colorectal liver metastases: a systematic review and meta-analysis. Cardiovascular and interventional radiology, 41(8), 1189-1204.
  • Gibbs, P., Heinemann, V., Sharma, N. K., Taieb, J., Ricke, J., Peeters, M., ... & Casado, A. R. (2018). Effect of primary tumor side on survival outcomes in untreated patients with metastatic colorectal cancer when selective internal radiation therapy is added to chemotherapy: combined analysis of two randomized controlled studies. Clinical colorectal cancer, 17(4), e617-e629.
Course summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
Course opens: 
07/01/2021
Course expires: 
06/30/2023

Constantinos T. Sofocleous, M.D., Ph.D.
Interventional Radiologist
Memorial Sloan Kettering Cancer Center
New York, New York

Constantinos T. Sofocleous, M.D., Ph.D., faculty for this educational activity, has disclosed that he has received grant/research support from BTG/BSX, SIRTEX, Ethicon J&J. He is also a consultant/advisory board member with BTG/BSX, SIRTEX, Ethicon J&J, Terumo and Varian and is on the speakers’ bureau with Ethicon J&J and has indicated that the presentation or discussion will not include off-label or unapproved product usage. 

Guilherme Rabinowits, M.D., conference director of this educational activity, has disclosed that he is a consultant with Sanofi and Regeneron.  

Ripal Gandhi, M.D., moderator for this educational activity, has disclosed that he is a consultant with Medtronic, BD, Cordis, Trisalus Life Sciences and Sirtex Medical. 

All of the relevant financial relationships listed for these individuals have been mitigated.

Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose with ineligible companies*.  

*Ineligible companies -- Companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
              
Baptist Health South Florida designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
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