Exhuming Cryptogenic Stroke

Cryptogenic stroke is frequently encountered in the hospital, and exhaustive, costly workups are required only by a minority of patients. This course will explain the algorithm of care after a standard workup determines that cryptogenic stroke should be considered.

Target Audience

Adult and Pediatric Neurologists, Neurosurgeons, Stroke Neurologists, Neuroradiologists, Diagnostic Radiologists, Critical Care Physicians, Neurointensivists, Emergency Medicine Physicians, Internal Medicine Physicians, Interventional Neuroradiologists, Family Physicians, General Internists, Rehabilitation and Pain Management Specialists, Clinical Pharmacists, as well as other specialists interested in the field of neuroscience.

Learning Objectives

  • Explain the criteria for diagnosing a cryptogenic stroke and implement the appropriate diagnostic algorithm after a standard workup determines that a stroke should be considered cryptogenic.
  • Recognize five less common stroke etiologies.
Additional information
  • Guidelines for the Echocardiographic Assessment of Atrial Septal Defect and Patent Foramen Ovale: From the American Society of Echocardiography and Society for Cardiac Angiography and Interventions Silvestry, Frank E., MD, FASE, Journal of the American Society of Echocardiography, Volume 28, Issue 8, 910-958.
  • Sanna, T., Diener, H. C., Passman, R. S., Di Lazzaro, V., Bernstein, R. A., Morillo, C. A., ... & Lindborg, K. (2014). Cryptogenic stroke and underlying atrial fibrillation. New England Journal of Medicine, 370(26), 2478-2486.
  • Kent, D. M., Ruthazer, R., Weimar, C., Mas, J. L., Serena, J., Homma, S., ... & Griffith, J. (2013). An index to identify stroke-related vs incidental patent foramen ovale in cryptogenic stroke. Neurology, 81(7), 619-625.
Course Summary
Available credit: 
  • 0.50 AMA PRA Category 1 Credit™
  • 0.50 General certificate of attendance
  • 0.50 Florida Board of Pharmacy
Course opens: 
Course expires: 

Felipe de los Rios, M.D.
Medical Director, Baptist Hospital Comprehensive Stroke Center and
Baptist Health South Florida Stroke Program
Voluntary Assistant Professor of Neurology
University of Cincinnati Department of Neurology and
Florida International University Herbert Wertheim College of Medicine


Kevin Abrams, M.D., indicated that he is a consultant and shareholder with Keystone Heart.

Guilherme Dabus, M.D., indicated that he is a consultant for Microvention/Terumo, Medtronic, Penumbra and Cerenovus, and on the speakers' bureau for Microvention/Terumo, Medtronic and Penumbra. He is a proctor for Medtronic. Dr. Dabus is also a shareholder with Surpass Medical/Stryker, Medina/Medtronic, InNeuro Co and Three Rivers Medical.

Daniel D’Amour, M.D., Felipe De Los Rios, M.D., Karel Fuentes, M.D., Sergio Gonzalez-Arias, M.D., Ph.D., Kunal Patel, M.S., Amy K. Starosciak, Ph.D., and Jayme Strauss, R.N., MSN, have no relevant financial relationship with ineligible companies* to disclose and have indicated that the presentation or discussion will not include off-label or unapproved product usage. 

Bruno V. Gallo, M.D., indicated that he is on speakers' bureau for Teva Pharmaceuticals and Sunovion Pharmaceuticals. He receives grant support for Medtronic International, Pfizer Pharmaceuticals, Glaxo-SmithKline and St. Jude Medical, Inc. Dr. Gallo serves as a consultant for Cyberonics, Teva Pharmaceuticals, St. Jude Medical, ONS Inc. and Sugimon LLC.

Italo Linfante, M.D., indicated that he is a consultant for Medtronic, Stryker and Penumbra. He is a stockholder with InNeuro Co.

Alberto Pinzon-Ardila, M.D., indicated that he is on the speakers' bureau for Sunovion Pharmaceuticals and UCB.

All of the relevant financial relationships listed for these individuals have been mitigated.

Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose with ineligible companies*. 

*Ineligible companies -- Companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
Baptist Health South Florida designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 0.50 AMA PRA Category 1 Credit™
  • 0.50 General certificate of attendance
  • 0.50 Florida Board of Pharmacy
Please login or register for a Baptist Health CME account to take this course.

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