From Xanthomata to Coronary Artery Disease: The Trail to the LDL Receptor

This course will explain the early work on the LDL receptor, a genetic cause of heart attacks that led to new ways of thinking about cholesterol metabolism. Learn more about the mechanism by which statins, a class of drugs, lower plasma LDL, reduce heart attacks and prolong life.

Target Audience

Cardiologists, Endocrinologists, Family Physicians, General Internists, Gynecologists, Internal Medicine Physicians, Physician Assistants and Fellows.

Learning Objectives

  • Recognize the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.
  • Analyze the three general concepts to the biology and medicine about cholesterol homeostasis. 
Additional information
Bibliography: 
  • Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase on serum lipoprotein and ubiquinone-10 levels in patients with familial hypercholesterolemia. N. Engl. J. Med. 305, 478–482.
  • Mabuchi, H., Sakai, T., Yoshimura, A., Watanabe, A., Wakasugi, T. and Watanabe, A. et al. (1983)  Reduction of serum cholesterol in heterozygous patients with familial hypercholesterolemia. Additive effects of compactin and cholestyramine. N.Engl. J. Med. 308, 609–613.
Course Summary
Available credit: 
  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 General certificate of attendance
Course opens: 
05/01/2017
Course expires: 
05/01/2019
Rating: 
0

William Virgil Brown, M.D.     
Director, Division of Arteriosclerosis and Lipid Metabolism 
Emory University School of Medicine
Charles Howard Candler Professor Emeritus
Atlanta, Georgia 

William Virgil Brown, M.D., has disclosed that he serves as a consultant to Akcea, Aegerion Pharmaceuticals, Esperion, Kowa Pharma and Merck, and that he is a member of the speakers bureaus for Merck, Kowa Pharma, Med Learning Group and the National Lipid Association. Also, Dr. Brown is a member of the Data and Safety Monitoring Committee for Amgen, Genzyme, Esperion and Sanofi. Dr. Brown has indicated that his presentations will not include discussion of off-label or unapproved usage.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
             
Baptist Health South Florida designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 General certificate of attendance
Please login or register for a Baptist Health CME account to take this course.

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