Precision Medicine and Dose-Dense Chemotherapy: Does It Work and Why?

This course will dissect the complex topic of precision medicine. Learners will come away with a better understanding of dose-dense chemotherapy and deciphering the enigma of breast cancers, DNA mutations and mapping these mutations to targeted chemotherapies. In precision medicine, molecular biology and the genetic profile of a person should determine optimal treatment. What does this mean and how does this rationale change the doctor-patient relationship?

RETURN TO MAIN PAGE: Breast Cancer for the Non-Oncologist: Supporting Your Patients Through Diagnosis and Treatment

Target Audience

General Surgeons, General Practitioners, Obstetricians and Gynecologists, Oncologists, Radiation Oncologists, Nurse Practitioners, Physician Assistants and all other interested healthcare professionals.

Learning Objectives

  • Explain the biological rationale behind dose-dense chemotherapy. 
  • Summarize cumulative data in support of dose-dense chemotherapy. 
  • Recognize the implications of the concept in the era of precision medicine. 
  • Assess the ongoing revolution in communication and how it influences thought patterns. 
  • Explain the effects of computer use during doctor-patient interactions. 
  • Identify the complex implications of changed communications in the precision medicine era.
Additional information
Bibliography: 
  • Skipper HE, Schabel FM Jr, Wilcox WS. Experimental Evaluation of Potential Anticancer Agents. XIII. On the Criteria and Kinetics Associated with “Curability” of Experimental Leukemia. Cancer Chemotherapy Reports, 35:1-111, 1964
  • Norton L. Use of dose-dense chemotherapy in the management of breast cancer. Clin Adv Hematol Oncol. 2006 Jan; 4(1):36-7. 
  • McArthur HL, Diab A, Norton, L. et al., A pilot study of preoperative single-dose ipilimumab and/or cryoablation in women with early-stage breast cancer with comprehensive immune profiling. Clin Cancer Res. 2016 Aug 26. PMID: 27566765 
Course Summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
Course opens: 
10/01/2017
Course expires: 
10/01/2019

Larry Norton, M.D.
Deputy Physician-in-Chief, Breast Cancer Programs
Medical Director, Evelyn H. Lauder Breast Center
Norna S. Sarofim Chair of Clinical Oncology
New York, New York

Larry Norton, M.D., indicated that neither he nor his spouse/partner has relevant financial relationships with commercial interest companies, and he will not include off-label or unapproved product usage in her presentation or discussion.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
              
Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
Please login or register for a Baptist Health CME account to take this course.

Required Hardware/Software

This site is best viewed on the two most recent stable releases of the following browsers for all public pages:

PCs Running Windows

  • Google Chrome (Preferred): Download free web browser for PC, Mac, phone and tablet. 
  • Internet Explorer (IE 11 and above recommended): You will be prompted to download videos before you are able to view. Click “download” to view video.  After a momentary pause, the recording will play. 
  • Mozilla Firefox: You may be prompted under the “This Connection is Untrusted” screen to add “cmeonline.baptisthealth.net” and “cdn.baptisthealth.net” under “add exceptions”.

Apple Computers Running OSX

  • Google Chrome (Preferred): Download free web browser for PC, Mac, phone and tablet. 
  • Safari
  • Mozilla Firefox: You may be prompted under the “This Connection is Untrusted” screen to add “cmeonline.baptisthealth.net” and “cdn.baptisthealth.net” under “add exceptions”.

This site uses a responsive design, which allows the page layout of elements to change depending on the screen resolution. Certain functionality may change based on the screen resolution of smaller screens, such as the number of columns in a table.

Technical Support: If you are experiencing technical difficulties or have received an error message, please send an email to CME@BaptistHealth.net and include a print screen of the error message, your browser name and version, username and URL where the error occurred. You can expect a response within 48 hours.