Miami Cardiac and Vascular Institute Grand Rounds: ATTR Cardiac Amyloidosis - Towards Earlier Diagnosis and Treatment
Transthyretin cardiac amyloidosis (ATTR-CA) demonstrates progressive, potentially fatal, and infiltrative cardiomyopathy caused by extracellular deposition of transthyretin-derived insoluble amyloid fibrils in the myocardium. Two distinct types of transthyretin (wild type or variant) become unstable, and misfolding forms aggregate, resulting in amyloid fibrils. ATTR-CA, which has previously been underrecognized and considered to be rare, has been increasingly recognized as a cause of heart failure with preserved ejection fraction among elderly persons. With the advanced technology, the diagnostic tools have been improving for cardiac amyloidosis. Recently, the efficacy of several disease-modifying agents focusing on the amyloidogenic process has been demonstrated. ATTR-CA has been changing from incurable to treatable. Nevertheless, there are still no prognostic improvements due to diagnostic delay or misdiagnosis because of phenotypic heterogeneity and co-morbidities. Thus, it is crucial for clinicians to be aware of this clinical entity for early diagnosis and proper treatment.
Join Dr. David Wolinsky, as he provides strategies to optimize treatment to improve patient outcomes.
|Live- Baptist Hospital 5MCVI|
Cardiologists, Interventional Cardiologists, Cardiothoracic Surgeons, Interventional Radiologists, Pulmonologists, Hematologists, General Internists, Primary Care Physicians, Intensivist, General Surgeons, Anesthesiologists, Emergency Medicine Physicians, Hospitalists, Radiation Technologists, Nurses and other interested healthcare providers.
- Recognize the myriad presentations of Transthyretin Cardiac Amyloidosis (ATTR-CA).
- Effectively implement referral processes to increase early detection of cardiac amyloid.
- Utilize TTcPYP imaging to diagnose ATTR-CA.
- Optimize treatment, including disease-modifying therapy, to improve outcomes.
David Wolinsky, M.D., FACC, MASNC
Section Head, Nuclear Cardiology
Director, Cardiac Amyloid Center
Cleveland Clinic Florida
David Wolinsky, M.D indicated that he is a consultant for Astellas and AKCEA, and he is a member of the Speakers’ Bureau for Astellas, AKCEA and Alnylam. He will not include off-label or unapproved product usage in his presentation or discussion.
James Benenati, M.D., indicated that he is a consultant for Penumbra and Bard. He is also a stock shareholder for Penumbra and Scientia. Barry Katzen, M.D. has indicated that he is a consultant for Boston Scientific, Phillips Medical, W.L. Gore and Bard. Dr. Theodore Feldman has indicated that he is a member of the Speakers’ Bureau for Regeneron, Sanofi, Boehringer Ingeldeim, and Novartis.
Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose.
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