Familial Hypercholesterolemia: Clinical Update

Familial hypercholesterolemia is associated with a high risk for premature coronary artery disease. Health professionals should be alert to the signs found during a physical examination and to the laboratory values suggestive of familial hypercholesterolemia in order to help prevent or slow the progression of coronary atherosclerosis.


Target Audience

Cardiologists, Endocrinologists, Family Physicians, General Internists, Gynecologists, Internal Medicine Physicians, Physician Assistants and Fellows. 

Learning Objective

  • Detect and properly manage familial hypercholesterolemia to prevent or slow progression of coronary atherosclerosis.
Additional information
  • Goldstein, Joseph L. "Familial hypercholesterolemia." (2001). http://emedicine.medscape.com/article/121298-overview  
  • Lambert, G., Charlton, F., Rye, K. A., & Piper, D. E. (2009). Molecular basis of PCSK9 function. Atherosclerosis, 203(1), 1-7.
  • Austin, M. A., Hutter, C. M., Zimmern, R. L., & Humphries, S. E. (2004). Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review. American journal of epidemiology, 160(5), 407-420.
  • Varret, M., Abifadel, M., Rabès, J. P., & Boileau, C. (2008). Genetic heterogeneity of autosomal dominant hypercholesterolemia. Clinical genetics, 73(1), 1-13.
  • Soutar, A. K., & Naoumova, R. P. (2007). Mechanisms of disease: genetic causes of familial hypercholesterolemia. Nature clinical practice Cardiovascular medicine, 4(4), 214-225.
Course Summary
Available credit: 
  • 0.75 ABIM MOC II
  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 General certificate of attendance
Course opens: 
Course expires: 

Paul E. Ziajka, M.D., Ph.D., FNLA     
Cardiologist, Private Practice
Assistant Professor, Internal Medicine
University of Central Florida College of Medicine
Clinical Assistant Professor, Department of Clinical Sciences
Florida State University School of Medicine
Orlando, Florida

Paul E. Ziajka, M.D., Ph.D., FNLA, disclosed that he receives grant/research support from Amgen, Regeneron and Sanofi; also, he is a member of the speakers bureau for Amgen, Amarin Pharma, Kowa Pharma, Regeneron and Sanofi. Dr. Ziajka has indicated that he will not include off-label or unapproved usage in his presentation or discussion.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose. 

Disclosure Policy and Disclaimer 

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
Baptist Health South Florida designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.75 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Your participation information will be shared with the ACCME, which will in turn report your points to ABIM. Successful completion of a course examination is required to earn ABIM MOC points.

NOTE: Maintenance of Certification (MOC) points will be automatically reported to the ABIM. Submissions are recorded in approximately 48 hours. You will receive an email when your credits have been processed.

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Available Credit

  • 0.75 ABIM MOC II
  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 General certificate of attendance
Please login or register for a Baptist Health CME account to take this course.

Required Hardware/Software

PC/Mac Users
PC/Mac Users

This site is supported on the most recent stable releases of the following browsers:

Click Here to Download Google Chrome
Google Chrome
Microsoft Edge
Microsoft Edge
Moxilla Firefox
Mozilla Firefox
Internet Explorer

Attention: Internet Explorer Users
This site offers limited support for Internet Explorer 11 (IE11). When using IE11, you will be prompted to download course videos instead of viewing them in the browser. After the course video downloads, the recordings will play.

Mobile Users
Mobile Users

This site is supported on the following mobile devices:

  • Apple iOS mobile devices running iOS 10 or later
  • Android mobile devices running Android 4.4 or later, with the latest release of Google Chrome or Mozilla Firefox
Technical Support
Technical Support

If you are experiencing technical difficulties or have received an error message, please send an email to CME@baptisthealth.net and include a print screen of the error message, your browser name and version, username and URL where the error occurred. You can expect a response within 48 hours.