Double Antiplatelet Therapy for Acute Ischemic Stroke Patients

Selected patients with acute ischemic stroke can benefit from a course of double antiplatelet therapy for the purpose of stroke prevention. This course details the disease mechanism by which this therapy works and review the inclusion and exclusion patient selection criteria as well as the different treatment modalities available.

Target Audience

Cardiologists, Vascular Surgeons, Interventional Radiologists, Interventional Cardiologists, Primary Care Physicians, Podiatrists, Emergency Medicine Physicians, General Internists and other interested healthcare providers.

Learning Objectives

  • Summarize the pathophysiology behind double antiplatelet therapy for acute ischemic stroke.
  • Identify patients with acute ischemic stroke who would benefit from double antiplatelet therapy.
  • Describe the available options for double antiplatelet therapy in acute ischemic stroke.
  • Implement double antiplatelet therapy for selected acute ischemic stroke patients for secondary stroke prevention.  
Additional information
  • Johnston, S. C., Amarenco, P., Denison, H., Evans, S. R., Himmelmann, A., James, S., ... & Wang, Y. (2020). Ticagrelor and aspirin or aspirin alone in acute ischemic stroke or TIA. New England Journal of Medicine, 383(3), 207-217.
  • Kleindorfer, D. O., Towfighi, A., Chaturvedi, S., Cockroft, K. M., Gutierrez, J., Lombardi-Hill, D., ... & Williams, L. S. (2021). 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke, 52(7), e364-e467.
  • Hao, Qor., Tampi, M., O’Donnell, M., Foroutan, F., Siemieniuk, R. A., & Guyatt, G. (2018). Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke high risk transient ischaemic attack: systematic review and meta-analysis. bmj, 363.
  • Johnston, S. C., Easton, J. D., Farrant, M., Barsan, W., Conwit, R. A., Elm, J. J., ... & Palesch, Y. Y. (2018). Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. New England Journal of Medicine, 379(3), 215-225.
Course Summary
Available credit: 
  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 General certificate of attendance
Course opens: 
Course expires: 

Felipe De Los Rios, M.D., FAHA 
Medical Director
Stroke Program – Miami Neuroscience Institute
Comprehensive Stroke Center – Baptist Hospital of Miami
Associate Professor of Neurology 
Florida International University, Herbert Wertheim College of Medicine 
University of Cincinnati College of Medicine
Department of Neurology & Rehabilitation Medicine

Felipe De Los Rios, M.D., speaker and conference director for this educational activity, is member of the speakers’ bureau for AstraZeneca and has indicated that the presentation or discussion will not include off-label or unapproved product usage.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose with ineligible companies.*

*Ineligible companies – Companies whose primary business is producing, marketing, selling, re-selling or distributing healthcare products used by or on patients.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
Baptist Health South Florida designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 0.75 AMA PRA Category 1 Credit™
  • 0.75 General certificate of attendance
Please login or register for a Baptist Health CME account to take this course.

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