Beyond Statins: Therapies to Decrease Cardiovascular Risk

PCSK9 is an established target for cholesterol-lowering therapies. Further study of PCSK9 regulatory mechanisms may identify additional control points for pharmacological inhibition of PCSK9-mediated LDLR degradation. PCSK9 function could reflect ancient roles in the fasting-feeding cycle and in linking lipoprotein metabolism with innate immunity. Dr. Peter A. McCullough will discuss the regulatory function of PCSK9, as well as results from recent clinical trials on the efficacy and safety of PCSK9.

Target Audience

Cardiologists, Interventional Cardiologists, Interventional Radiologists, General Internists, Primary Care Physicians, Intensivists, General Surgeons, Gynecologists, Anesthesiologists, Emergency Medicine Physicians, Hospitalists, Nurses, Nurse Practitioners, Pharmacists and other interested healthcare providers.

Learning Objectives

  • Review global cardiovascular risk.
  • Demonstrate the regulatory function of PCSK9.
  • Synthesize the results of randomized trials with respect to efficacy and safety of PCSK9.
Additional information
Bibliography: 

Lagace, T. A. (2014). PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells. Current opinion in lipidology, 25(5), 387.

Related Topics

Miami Cardiac & Vascular Institute Online Series (Multiple Modules)
Miami Cardiac & Vascular Institute offers continuing medical education on the latest innovations in clinical care.
Course Summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Pharmacy
Course opens: 
05/01/2018
Course expires: 
05/01/2020

Peter A. McCullough, M.D., MPH, FACP, FACC, FCCP, FAHA, FNKF, FNLA, FCRSA
Vice Chief of Medicine
Baylor University Medical Center
Dallas, Texas
Principal Faculty in Internal Medicine
Texas A & M University Health Sciences Center
Dallas, Texas

Peter A. McCullough, M.D., has indicated that neither he nor his spouse/partner has relevant financial relationships with commercial interest companies, and he will not include off-label or unapproved product usage in his presentation or discussion.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
             
Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Pharmacy
Please login or register for a Baptist Health CME account to take this course.

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