COURSE DESCRIPTION:

Platelet-rich plasma (PRP) therapy is increasingly used in the management of osteoarthritis, tendinopathy, and other musculoskeletal conditions; however, variability in PRP preparation and reporting can make it difficult to determine the actual platelet dose delivered to patients. This educational activity will provide a practical framework for understanding and calculating the absolute platelet dose delivered by a PRP preparation based on whole blood volume, baseline platelet count, and platelet recovery rate, while emphasizing why device name, processing protocol, or reported platelet concentration alone may not adequately define the delivered dose.

The presentation will review evidence-based platelet dosing thresholds for intra-articular and tendon or soft-tissue applications and demonstrate how delivered platelet dose can be incorporated into clinical decision-making. Participants will also examine conflicting PRP clinical outcome data by considering differences in platelet dose and will discuss the limitations of current dose-response evidence, including the lack of a dedicated dose-response randomized controlled trial in rotator cuff tendinopathy and the potential influence of operator technique and patient selection on reported outcomes.

TARGET AUDIENCE:

Orthopedists, internists, family medicine practitioners, emergency medicine physicians, urgent care physicians, podiatrists, physician assistants, athletic trainers, nurse practitioners, residents, medical students and all other interested healthcare providers.

LEARNING OBJECTIVES:

• Calculate the absolute platelet dose delivered by a PRP preparation from whole blood volume, baseline platelet count, and platelet recovery rate — and explain why device name, spin protocol, or fold-increase reported alone does not define a dose.
• Apply evidence-based dosing thresholds to clinical decision-making — ≥10 billion total platelets for intra-articular knee and hip osteoarthritis, and ≥3.5 billion per injection for tendon and soft-tissue targets including rotator cuff, gluteal, and lateral epicondyle.
• Appraise conflicting PRP outcome trials by stratifying them according to delivered platelet dose, and identify the limitations of the current dose–response evidence, including the absence of a dedicated dose–response RCT in rotator cuff tendinopathy and the confounding of dose by operator technique and patient selection.

FACULTY

Don Buford, M.D.
Orthopedic Surgeon
Dallas, TX. 
 

Don Buford, M.D., faculty of this educational activity, has indicated that the do not have any relevant financial relationships with ineligible companies* to disclose. 

Charles M. Lawrie, M.D., M.Sc, conference director for this activity, has indicated that the do not have any relevant financial relationships with ineligible companies* to disclose. 

Eduardo Cartin - Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships with ineligible companies* to disclose. 

Drialys Leal, M.S., LAT, ATC - Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships with ineligible companies* to disclose. 

*Ineligible companies – Companies whose primary business is producing, marketing, selling, re-selling or distributing healthcare products used by or on patients.

Disclosure Policy and Disclaimer

ACCREDITATION STATEMENTS AND CREDITS

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.

Baptist Health South Florida designates this live activity for a maximum of 1 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This activity has been approved for 1 credit hour, CE Broker Course #20-1376661, by the Florida Boards of Medicine, Osteopathic Medicine, Florida Board of Podiatric Medicine and Physician Assistants.

This activity has also been approved for 1 credit for Nurse Practitioners, Nurses, Pharmacists and Pharmacy Techs and Athletic Trainers . Baptist Health South Florida CE Broker Provider #50-182.

American Board of Surgery - Maintenance of Certification (MOC) - Accredited CME - General Surgery

Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME of the American Board of Surgery’s Continuous Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABS credit.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME of the American Board of Orthopaedic Surgery’s Maintenance of Certification program. It is the CME activity provider's responsibility to submit learner completion information to ACCME for the purpose of granting ABOS credit.