Evidence-based Clinical Care: Source-Based Antibiotic Power Plans for Sepsis

Sepsis, severe sepsis and septic shock are significant healthcare concerns for the U.S. population because of their high prevalence, morbidity, mortality and medical costs. Mortality from sepsis increases 8% for every hour that antibiotic treatment is delayed. Sepsis is a leading cause of death in U.S. hospitals. This course provides a review of the source-based antibiotic power plans for sepsis utilized at Baptist Health South Florida.

Note to Physicians: Be sure to bookmark this course to access all protocols, pathways, policies and procedures at your convenience via your CME Portal account. All power plans are available in Cerner. All EBCC deliverables will be available on the EBCC website.

Target Audience

Emergency Department Practitioners, Hospitalists, Intensivists, Infectious Disease Specialists, Advanced Practice Registered Nurses, Physician Assistants, Pharmacists, Pharmacy Technicians, Laboratory Technologists and Nurses. 

Learning Objectives

  • Identify key considerations for empiric antibiotic selection in patients with sepsis.
  • Discuss guideline recommendations for antimicrobial therapy in the setting of sepsis or septic shock.
Additional information
Bibliography: 
  • Antibiotic Resistance. (2023). Resistance Map. Retrieved February 17, 2023, from https://resistancemap.onehealthtrust.org/
  • Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. (2020, October 1). Infectious Diseases Society of America. Retrieved February 17, 2023, from https://www.idsociety.org/practice-guideline/community-acquired-pneumonia-cap-in-adults/
  • Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., Schorr, C., Simpson, S., Wiersinga, W. J., Alshamsi, F., Angus, D. C., Arabi, Y., Azevedo, L., Beale, R., Beilman, G., . . . Levy, M. (2021). Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Critical Care Medicine, 49(11), e1063–e1143.
  • Kolman, K. B. (2019). Cystitis and Pyelonephritis. Primary Care: Clinics in Office Practice, 46(2), 191–202.
  • Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. (2017, July 14). Infectious Diseases Society of America. Retrieved February 17, 2023, from https://www.idsociety.org/practice-guideline/hap_vap/
  • Mazuski, J. E., Tessier, J. M., May, A. K., Sawyer, R. G., Nadler, E. P., Rosengart, M. R., Chang, P. K., O’Neill, P. J., Mollen, K. P., Huston, J. M., Diaz, J. J., & Prince, J. M. (2017). The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection. Surgical Infections, 18(1), 1–76. 
  • Montravers, P., Augustin, P., Zappella, N., Dufour, G., Arapis, K., Chosidow, D., Fournier, P., Ribeiro-Parienti, L., Marmuse, J. P., & Desmard, M. (2015). Diagnosis and management of the postoperative surgical and medical complications of bariatric surgery. Anaesthesia Critical Care &Amp; Pain Medicine, 34(1), 45–52. 
  • Surviving Sepsis International Guidelines. (2021, October 4). Society of Critical Care Medicine. Retrieved February 17, 2023, from https://www.sccm.org/Clinical-Resources/Guidelines/Guidelines/Surviving-Sepsis-Guidelines-2021
  • Surviving Sepsis International Guidelines 2021. (2021, October 4). Society of Critical Care Medicine. Retrieved February 17, 2023, from https://www.sccm.org/Clinical-Resources/Guidelines/Guidelines/Surviving-Sepsis-Guidelines-2021
  • Yealy, D. M., Mohr, N. M., Shapiro, N. I., Venkatesh, A., Jones, A. E., & Self, W. H. (2021a). Early Care of Adults With Suspected Sepsis in the Emergency Department and Out-of-Hospital Environment: A Consensus-Based Task Force Report. Annals of Emergency Medicine, 78(1), 1–19. 
  • Yealy, D. M., Mohr, N. M., Shapiro, N. I., Venkatesh, A., Jones, A. E., & Self, W. H. (2021b). Early Care of Adults With Suspected Sepsis in the Emergency Department and Out-of-Hospital Environment: A Consensus-Based Task Force Report. Annals of Emergency Medicine, 78(1), 1–19. 
Resources: 

How to save power plans (EBCC order sets) to your favorites on CERNER? Click here to access video tutorial.

Course Summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Florida Board of Laboratory Personnel
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Pharmacy
Course opens: 
03/01/2023
Course expires: 
02/28/2025

Timothy P. Gauthier, Pharm.D., BCPS, BCIDP
Director, ID PGY2 Pharmacy Residency Program 
Manager, Antimicrobial Stewardship Clinical Program
Baptist Health South Florida
Miami, Florida

Richard Levine, M.D.
Infectious Disease Specialist
Baptist Hospital, Doctors Hospital and South Miami Hospital
Chairman, Antimicrobial Stewardship Committee, Doctors Hospital
Baptist Health South Florida
Miami, Florida

Lourdes R. Menendez, Pharm.D., BCPS
PGY2 Infectious Diseases Pharmacy Resident
Baptist Health South Florida
Miami, Florida

Timothy P. Gauthier, Pharm. D., BCPS, BCIDP, faculty for this educational activity, is a consultant with Pattern Biosciences (formerly Klaris Diagnostics), DoseMeRx by Tabula Rasa, Pfizer and MeMed. All of the relevant financial relationships listed for this individual have been mitigated.

Richard L. Levine, M.D., faculty for this educational activity, has no relevant financial relationships to disclose with ineligible companies*.

Lourdes R. Menendez, Pharm. D., BCPS, content contributor for this educational activity, has no relevant financial relationships to disclose with ineligible companies*.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose with ineligible companies*. 

*Ineligible companies – Companies whose primary business is producing, marketing, selling, re-selling or distributing healthcare products used by or on patients

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
              
Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Florida Board of Laboratory Personnel
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.00 Florida Board of Pharmacy
Please login or register for a Baptist Health CME account to take this course.

Required Hardware/Software

PC/Mac Users
PC/Mac Users

This site is supported on the most recent stable releases of the following browsers:

Click Here to Download Google Chrome
Google Chrome		Microsoft Edge
Microsoft Edge		Safari
Safari		Moxilla Firefox
Mozilla Firefox
Internet Explorer

Attention: Internet Explorer Users
This site offers limited support for Internet Explorer 11 (IE11). When using IE11, you will be prompted to download course videos instead of viewing them in the browser. After the course video downloads, the recordings will play.

Mobile Users
Mobile Users

This site is supported on the following mobile devices:

  • Apple iOS mobile devices running iOS 10 or later
  • Android mobile devices running Android 4.4 or later, with the latest release of Google Chrome or Mozilla Firefox
Technical Support
Technical Support

If you are experiencing technical difficulties or have received an error message, please send an email to CME@baptisthealth.net and include a print screen of the error message, your browser name and version, username and URL where the error occurred. You can expect a response within 48 hours.