An Update on Accelerated Partial-Breast Irradiation

Multiple adjuvant radiation therapy options currently exist for women following breast-conserving surgery, including standard fractionated whole-breast irradiation (WBI), accelerated whole-breast irradiation (AWBI) and accelerated partial-breast irradiation (APBI). Dr. Atif Jalees Khan will help participants identify optimal candidates for partial breast irradiation.     

Target Audience

Oncologists, Radiation Oncologists, Hematology Oncologists, Radiation Therapists, General Surgeons, General Practitioners, Obstetricians and Gynecologists, Advanced Registered Nurse Practitioner, Nurses, Patient Navigators and all other interested healthcare professionals.

Learning Objectives

  • Analyze the rationale for partial-breast irradiation (PBI).
  • Compare and assess the eligibility and outcomes of trial data directly comparing whole-breast and partial-breast irradiation. 
  • Summarize the differences in local recurrences reported in low-risk omission of radiotherapy trials versus local recurrences reported in PBI trials.
Additional information
Bibliography: 
  • Schmitz, A. C., van den Bosch, M. A., Loo, C. E., Willem, P. T. M., Bartelink, H., Gertenbach, M., ... & Gilhuijs, K. G. (2010). Precise correlation between MRI and histopathology–exploring treatment margins for MRI-guided localized breast cancer therapy. Radiotherapy and Oncology, 97(2), 225-232.
  • Nguyen, B. T., Deb, S., Fox, S., Hill, P., Collins, M., & Chua, B. H. (2012). A prospective pathologic study to define the clinical target volume for partial breast radiation therapy in women with early breast cancer. International Journal of Radiation Oncology* Biology* Physics, 84(5), 1116-1122.
  • Bentzen, S.M., & Yarnold, J.R. (2010. Reports of unexpected late side effects of accelerated partial breast irradiation – radiobiological considerations. International journal of radiation oncology, biology, physics, 77(4), 969-973.
  • Vaidya, J. S., Joseph, D. J., Tobias, J. S., Bulsara, M., Wenz, F., Saunders, C., ... & Baum, M. (2010). Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. The Lancet, 376(9735), 91-102.
Course Summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
Course opens: 
11/01/2021
Course expires: 
10/31/2023

Atif Jalees Khan, M.D.
Department of Radiation Oncology
Enterprise-wide Director of Breast Radiotherapy Services
Attending, Memorial Hospital 
Member, Memorial Sloan Kettering Cancer Center
New York, N.Y.

Atif Jalees Khan, M.D., faculty for this educational activity, has received research support from Clovis Oncology, Varian and Merck. He has received royalties/patents from Rutgers University/Biohaven Pharm, and has individual stocks/stock options with Novavax/Xtrava. He has indicated that the presentation or discussion will not include off-label or unapproved product usage.

Guilherme Rabinowits, M.D., conference series director, has indicated that he is a consultant with Sanofi, Regeneron and Castle.

All of the relevant financial relationships listed for these individuals have been mitigated.
  
Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose with ineligible companies.*

*Ineligible companies – Companies whose primary business is producing, marketing, selling, re-selling or distributing healthcare products used by or on patients.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
              
Baptist Health South Florida designates this enduring material for a maximum of 1 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
  • 1.00 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
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