Pediatric Osteosarcoma Update

Osteosarcoma, the most common type of primary malignant bone tumor, is defined by the presence of malignant mesenchymal cells producing osteoid or immature bone. During this lecture, Dr. Meyers will explain the evolving role of genomic profiling in diagnosing and treating pediatric osteosarcoma, as well as, reviewing the use of histologic necrosis following initial chemotherapy in the treatment of pediatric osteosarcoma.   

Target Audience

Pediatricians, Pediatric Oncologists, Hematologists/Oncologists, Infectious Disease Pediatricians, Pediatric General Internists, Family Physicians, Neonatologists, ED Physicians, Pharmacists and all other interested healthcare providers who care for children with cancer.

Learning Objectives

  • Summarize the meaning and use of histologic necrosis following initial chemotherapy in the treatment of osteosarcoma.  
  • Describe the evolving role of genomic profiling in the diagnosis and treatment of osteosarcoma.
Additional information
  • MacEwen, E. G., Kurzman, I. D., Rosenthal, R. C., Smith, B. W., Manley, P. A., Roush, J. K., & Howard, P. E. (1989). Therapy for osteosarcoma in dogs with intravenous injection of liposome-encapsulated muramyl tripeptide.
  • Meyers, P. A., Schwartz, C. L., Krailo, M. D., Healey, J. H., Bernstein, M. L., Betcher, D., ... & Kleinerman, E. (2008). Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival-a report from the Children's Oncology Group. Journal of clinical oncology, 26(4), 633-638.
  • Whelan, J. S., Bielack, S. S., Marina, N., Smeland, S., Jovic, G., Hook, J. M., ... & Calaminus, G. (2015). EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment. Annals of Oncology, 26(2), 407-414.
Course Summary
Available credit: 
  • 0.50 AMA PRA Category 1 Credit™
  • 0.50 General certificate of attendance
  • 0.50 Florida Board of Pharmacy
Course opens: 
Course expires: 

Paul A. Meyers, M.D. 
Pediatric Oncologist
Chief of Sarcoma Service 
Vice Chair for Clinical Affairs
Memorial Sloan Kettering Cancer Center
New York, New York

Paul A. Meyers, M.D., faculty for this educational activity,  has indicated that he is a consultant with Boehringer Ingelheim, Genentech and Eli Lilly and is on the speakers' bureau with Genentech. He is a shareholder with Amgen. He will include off-label or unapproved product usage in his presentation or discussion.

All of the relevant financial relationships listed for this individual has been mitigated.

Symposium Directors
This online course is a highlight from the Kids with Cancer Symposium.

Doured Daghistani, M.D.
Symposium Director
Baptist, Homestead and South Miami Hospitals
Miami, Florida

Ziad Khatib, M.D. 
Director of Medical Neuro-Oncology
Division of Pediatric Hematology/Oncology
Clinical Associate Professor
Department of Pediatrics
Florida International University
Kidz Medical Services
Nicklaus Children’s Hospital
Miami, Florida

Doured Dahgistani, M.D., and Ziad Khatib, M.D., symposium directors, have no relevant financial relationship with ineligible companies* to disclose.

Non-faculty contributors and others involved in the planning, development, and editing/review of the content have no relevant financial relationships to disclose with ineligible companies*.  

*Ineligible companies -- Companies whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
Baptist Health South Florida designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Available Credit

  • 0.50 AMA PRA Category 1 Credit™
  • 0.50 General certificate of attendance
  • 0.50 Florida Board of Pharmacy
Please login or register for a Baptist Health CME account to take this course.

Required Hardware/Software

PC/Mac Users
PC/Mac Users

This site is supported on the most recent stable releases of the following browsers:

Click Here to Download Google Chrome
Google Chrome
Microsoft Edge
Microsoft Edge
Moxilla Firefox
Mozilla Firefox
Internet Explorer

Attention: Internet Explorer Users
This site offers limited support for Internet Explorer 11 (IE11). When using IE11, you will be prompted to download course videos instead of viewing them in the browser. After the course video downloads, the recordings will play.

Mobile Users
Mobile Users

This site is supported on the following mobile devices:

  • Apple iOS mobile devices running iOS 10 or later
  • Android mobile devices running Android 4.4 or later, with the latest release of Google Chrome or Mozilla Firefox
Technical Support
Technical Support

If you are experiencing technical difficulties or have received an error message, please send an email to and include a print screen of the error message, your browser name and version, username and URL where the error occurred. You can expect a response within 48 hours.