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LEARNING OBJECTIVES:

• Discuss indications of the different ADCs in metastatic breast cancer
• Differentiate the toxicity profiles of datopotamab deruxtecan (Dato-DXd), sacituzumab govitecan, and trastuzumab deruxtecan (T-DXd) (fatigue, nausea, diarrhea, stomatitis, neutropenia).
• Discuss evidence-based, proactive strategies to prevent and manage ADC-related adverse events, including antiemetic protocols, diarrhea management algorithms, growth factor use, oral care for stomatitis, and dose-modification approaches.
• Discuss clinical and radiographic signs of ADC-associated ILD/pneumonitis and management.
   

FACULTY AND DISCLOSURES:

Reshma L. Mahtani, DO
Chief of Breast Medical Oncology
Miami Cancer Institute 
Baptist Health South Florida
Member, Memorial Sloan Kettering Cancer Alliance

Reshma L. Mahtani, DO, faculty for this educational activity, is a Consultant for Agendia, AztraZeneca, Daiichi, Eisai, Genentech, Gilead, Hologic, Lilly, Novartis, Pfizer, Puma and Stemline.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships with ineligible companies* to disclose.

*Ineligible companies – Companies whose primary business is producing, marketing, selling, reselling, or distributing healthcare products used by or on patients.

Disclosure Policy and Disclaimer

ACCREDITATION STATEMENTS AND CREDITS

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.

Baptist Health South Florida designates this live activity for a maximum of 1 AMA PRA Category 1 Credit™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.   

This activity has been approved for 1 credit hour, CE Broker Course #20-1346668, by the Florida Boards of Medicine, Osteopathic Medicine and Physician Assistants.  

This activity has also been approved for 1 credit for Nurse Practitioners, Nurses, Pharmacists and Pharmacy Techs, and Laboratory Personnel. Baptist Health South Florida CE Broker Provider #50-182.