Clostridioides difficile (C. difficile) Testing and Management

Clostridioides difficile is the most commonly recognized cause of infectious diarrhea in the healthcare setting. In this course, Jorge Murillo, M.D., and Alice Margulis, Pharm.D., will discuss inpatient testing and clinical management via clinical case presentations.

Target Audience

Physicians, mid-level practitioners, nurses, nurse practitioners, physician assistants, pharmacists and other healthcare professionals. 

Learning Objectives

  • Explain the prevalence, risk factors and clinical manifestations of Clostridioides difficile infection (CDI) and distinguish clinical scenarios when C. difficile testing is advisable.
  • Implement a multimodal approach to CDI management.
Additional information
Bibliography: 
  • McDonald, L. C., Gerding, D. N., Johnson, S., Bakken, J. S., Carroll, K. C., Coffin, S. E., ... & Loo, V. (2018). Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clinical Infectious Diseases, 66(7), e1-e48.
  • U.S. Centers for Disease Control and Prevention’(2019). Antibiotic Resistance Threats in the United States, 2019. U.S. Department of Health and Human Services. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf
  • Deshpande, A., Pasupuleti, V., Thota, P., Pant, C., Rolston, D. D., Sferra, T. J., ... & Donskey, C. J. (2013). Community-associated Clostridium difficile infection and antibiotics: a meta-analysis. Journal of Antimicrobial Chemotherapy, 68(9), 1951-1961.
  • See I, Mu Y, Cohen J, et al. NAP1 Strain Type Predicts Outcomes from Clostridium difficile Infection. Clinical Infectious Diseases. 2014; 58(10): 1394-1400.
  • Burdette SD, Bernstein JM. Does the Nose Know? The Odiferous Diagnosis of Clostridium difficile-Associated Diarrhea. Clinical Infectious Diseases. 2007; 44(8): 1142.
  • Rao K, Berland D, Young C, et al. The Nose Knows Not: Poor Predictive Value of Stool Sample Odor for Detection of Clostridium difficile. Clinical Infectious Diseases. 2013; 56(4): 615–616.
  • Bobenchik A. Battleground Zero: A Review of Best Practice Recommendations for Clostridioides (Clostridium) difficile Testing. Clinical Microbiology Newsletter. 2019; 41(20): 175–183.
  • Schuetz A. Diagnosis of C. difficile – Why So Difficult? The Journal of Applied Laboratory Medicine. 2018.
Course summary
Available credit: 
  • 1.25 ABIM MOC
  • 1.25 AMA PRA Category 1 Credit™
  • 1.25 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.25 Florida Board of Pharmacy
Course opens: 
06/01/2020
Course expires: 
05/31/2023

Alice Margulis, Pharm.D., BCIDP
Antimicrobial Stewardship Clinical Pharmacy Specialist
South Miami Hospital

Conference Director 
Jorge Murillo, M.D., FIDSA, FACP 
Infectious Diseases Physician

Jorge Murillo, M.D., FIDSA, FACP, is on the speakers bureau for Merck and he will not include off-label or unapproved product usage in his presentation or discussion.

Alice Margulis, Pharm.D., BCIDP, indicated that neither she nor her spouse/partner has relevant financial relationships with commercial interest companies, and she will not include off-label or unapproved product usage in her presentation or discussion.

Non-faculty contributors and others involved in the planning, development and editing/review of the content have no relevant financial relationships to disclose.

Disclosure Policy and Disclaimer

Baptist Health South Florida is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. Baptist Health has been re-surveyed by the ACCME and awarded Commendation for 6 years as a provider of CME for physicians.
              
Baptist Health South Florida designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.25 Medical Knowledge MOC points in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Your participation information will be shared with the ACCME, which will in turn report your points to ABIM. Successful completion of a course examination is required to earn ABIM MOC points.

NOTE: Maintenance of Certification (MOC) points will be automatically reported to the ABIM. Submissions are recorded in approximately 48 hours. You will receive an email when your credits have been processed.

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

Available Credit

  • 1.25 ABIM MOC
  • 1.25 AMA PRA Category 1 Credit™
  • 1.25 General certificate of attendance
  • 1.00 Nurse Practitioners
  • 1.00 Florida Board of Nursing
  • 1.25 Florida Board of Pharmacy
Please login or register to take this course.

NOTE: Maintenance of Certification (MOC) points will be automatically reported to the ABIM. Submissions are recorded in approximately 48 hours. You will receive an email when your credits have been processed.

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